Pharmacodynamics. The drug is Gastal durabolin 100 antacid buffer that eliminates the acidity of the stomach and associated disorders function. Hydroxide-magnesium carbonate gel is the aluminum acts as an antacid buffer, reducing gastric acidity increased to physiological levels (pH 5.3), thus contributing to, normal digestion without an increase of the secretory activity. Magnesium carbonate has a neutralizing effect quickly for a prolonged period, increasing the antacid effect.
The antacid effect of the drug begins immediately after taking the tablets, the duration is about 2 hours. One tablet Gustav ® neutralizes 21.5 mmol hydrochloric acid. The recommended dose of the drug raises the pH to 3 to 5, eliminating the thus free hydrochloric acid. Gastal ® inhibits the action of pepsin, lysolecithin and bile acids.
It proved that antacids that contain aluminum hydroxide, enhance the protective and regenerative processes in the gastric mucosa. Cytoprotective effect of aluminum ion include: increased secretion of mucin and sodium bicarbonate, and prostaglandin E2 activation N0, epidermal growth factor accumulation at the site of mucosal damage, increased concentration of durabolin 100 phospholipids in the stomach wall. The mechanism of action is not fully understood.
Pharmacokinetics. Preparation Gastal ® has no systemic effect in patients with normal renal function.
After reaction with hydrochloric acid of the gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline medium of the intestine and excreted in the intestine as insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in the gastric juice to form magnesium chloride, which has a mild osmotic laxative neutralizing aluminum hydroxide pinning effect in the small intestine. Magnesium ions are derived intestine as an insoluble carbonate.
Symptomatic treatment of hyperacidity states (including accompanied by heartburn), associated with gastric ulcer and duodenal ulcer, gastritis, reflux esophagitis.
Hypersensitivity to aluminum salts, magnesium durabolin 100 or other ingredients; severe renal impairment; children under 6 years of age.
Chronic renal failure; children older than 6 years.
Pregnancy and lactation
The drug Gastal has no systemic effects are not excreted in breast milk. However, use of the drug during pregnancy and lactation is possible only under medical supervision.
Dosing and Administration
drug is recommended to take 1-2 tablets 4-6 times a day, about one hour after meals and before going to bed, but not more than 8 tablets per day. The duration of intake should not exceed 2 weeks. The same dose is recommended for the treatment of heartburn, regardless of the meal.
Children 6 to 12 years of
drug is recommended to take at a dose of half of the recommended dose for adults. The tablets should be taken orally, gradually dissolving in the mouth.
When using the drug in recommended doses, side durabolin 100 undesired side reactions are uncommon: nausea, constipation, diarrhea, change in taste. In exceptional cases, allergic reactions occur.
Symptoms of acute overdose have not been registered.
Perhaps the development of more severe adverse reactions from the gastrointestinal tract (constipation, diarrhea). Displaying symptomatic treatment.
Interaction with other drugs
drug Gastal enhances the activity of levodopa, and nalidixic acid. The activity of tetracyclines, quinolones, acetylsalicylic acid, isoniazid, naproxen, iron preparations, indomethacin, chlorpromazine, [3-blockers, diflunisal, H2-histamine blockers, vitamins A, D, E, K, anticoagulants, barbiturates, and cardiac glycosides reduced. In this connection, the above drugs to be taken one hour before or 2 hours after taking the drug Gastal. M-holinoblokatory, slowing gastric motility, prolong the effect of the drug.
dose reduction and shortened the period of treatment is indicated for patients with reduced weight and for children.
Patients with reduced kidney function should avoid prolonged use of the drug in high doses. Continuous intake of more than 2 weeks is possible only after consulting your doctor.
Effects on ability to drive vehicles and use machines: no effect.
Tablets for resorption (cherry, mint).
At 6 tablets in blister PVC / PVDC and aluminum foil.
At 4 or 8 blisters with instruction for use in a cardboard box. cypoprime