When administered primidone is rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability is 90-100%. The maximum concentration of primidone plasma observed after 3 hours. The half-life is 7-14 hours. Primidone, phenobarbital is metabolized to form (about 20%) and feniletilmalonamida. About 40% of primidone is excreted unchanged durabolin price in the urine.
- epilepsy of various origins, manifested mainly large seizures;
- focal, myoclonic, akinetic seizures (less efficient);
- essential tremor
Hexamidine taken orally after a meal. The initial daily dose for adults is 125 mg (1-2 doses), then gradually increase the dose every 3 days by 125 mg to achieve the desired effect. The maximum dose for adults: single – 750 mg daily – 2 years
Children, depending on age appoint 125-500 mg / day. The maximum daily dose – 1 g (2 doses).
Perhaps: light drowsiness, lethargy, dizziness, headache, psychotic reactions, nystagmus, ataxia, nausea, vomiting.
Rare: leukopenia, lymphocytosis, megaloblastic durabolin price anemia, “lupus” syndrome, arthralgias.
- diseases of the liver and / or kidney problems;
- hematopoietic system diseases;
- lactation (breastfeeding);
- Hypersensitivity to preparau
Caution must be exercised in the appointment of hexamidine children, the elderly and immunocompromised patients. Hexamidine can be used in the complex anticonvulsant therapy.
Abolition of the drug and its replacement is carried out gradually. With prolonged use may develop drug dependence.
In the case of megaloblastic anemia should stop taking the drug and begin the treatment with folic acid and / or vitamin B12.
Prolonged use of anticonvulsants to patients may be necessary to the appointment of additional quantities of vitamin D for the prevention of osteomalacia.
There are reports of a possible association durabolin price between the use of anticonvulsant drugs and an increase in the incidence of congenital malformations.
If necessary, the appointment during lactation should decide the issue of termination of breastfeeding.
Be wary appoint hexamidine patients involved in potentially hazardous activities that require increased attention and psychomotor speed reactions.
When concomitant administration of paracetamol and hexamidine last action can be weakened. Hexamidine also reduces the clinical efficacy of quinidine. Inhibition of CNS and respiratory depression may be increased by concomitant use of hexamidine and means oppressive central nervous system. anabolic steroids online pharmacy
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