Combination drug whose action is due to the components included in its composition.
Gentamicin Sulfate – broad-spectrum antibiotic of the aminoglycoside, bactericidal effect. Effective against microorganisms koagulazopozitivnyh and coagulase-negative staphylococci (including Staphylococcus aureus), Escherichia coli, indolpolozhitelnyh and indolotritsatelnyh species Proteus, Pseudomonas aeruginosa, various types of groups Klebsiella – Enterobacter – Serratia, species Citrobacter, Salmonella, Shigella, Moraxella (including Moraxella lacunata ) and of Neisseria, such as Neisseria gonorrhoeae.
Betamethasone disodium phosphate – glucocorticosteroid (GCS), has a local anti-inflammatory effect, suppressing cellular and fibrinous exudation and normalizing the increased capillary permeability, which is manifested decreasing local congestion, edema and effusion. In allergic or traumatic lesion of corneal corticosteroids suppress fibroblast proliferation and post-inflammatory corneal neovascularization, thus preserving its transparency.
- Staphylococcal Blepharoconjunctivitis, keratoconjunctivitis, conjunctivitis secondarily infected; blepharitis, keratitis, episcleritis, dacryocystitis, barley (meybomit), the anterior eye injuries as a result of the ingress of foreign bodies, the impact of radiation, thermal and chemical burns, as well as in the postoperative period;
- acute and chronic otitis externa, secondarily infected durabolin diseases of the outer ear canal eczema, seborrheic dermatitis and contact.
- hypersensitivity to any component of the drug;
- keratitis caused by herpes simplex virus (treelike keratitis)
- viral diseases of the cornea and conjunctiva (such as varicella)
- mycobacterial or fungal infections of the eye or ear,
- vaccine (dermatosis that occurs as a complication of smallpox vaccination);
- State, accompanied by thinning of the cornea or sclera durabolin (for example, after removal of a corneal foreign body);
- absence or perforation of the tympanic membrane;
- Children’s age – up to 8 years;
- lactation (due to lack of information);
- during treatment is not recommended to wear soft contact lenses (due to the presence of benzalkonium chloride preparation).
- open-angle glaucoma, high myopia or diabetes, family history;
- infection caused by herpes simplex virus.
Use during pregnancy and lactation
Garazon ® should not be administered during pregnancy unless the potential benefit of its use for the mother justifies the potential risk to the durabolin fetus.
It is not known whether the components of the preparation allocated Garazon ® in the composition of breast milk. Therefore, during the use of the drug should abandon breastfeeding.
Dosage and administration
Used in adults and children older than 8 years in the conjunctival sac or the external auditory canal. In diseases of the eye : The dosage should be determined individually for each patient. Typically 1-2 drops instilled in the conjunctival sac of the affected eye 3-4 times a day. In the acute stage of the frequency of use of the drug can be increased to 2 drops per hour, or every 2 chasa; later, when the disease becomes controlled, the use of the frequency decreases. The total duration of topical treatment depends on the nature and severity of the disease. In the absence of therapeutic effect within 14 days after the start of treatment the further use of the drug is not appropriate. In diseases of the ear : the outer ear canal should be cleaned before using the product. The recommended initial dose – 3-4 drops of 2 to 4 times a day. The patient should lie on their sides so that the affected ear was drawn up; after instillation of the solution should remain in this position for a few minutes to allow the penetration of the drug into the ear canal. If reduction of the inflammatory phenomena should gradually reduce the dose, and stop using the product after the disappearance of symptoms. If necessary, the inside of the outer ear canal, you can enter a cotton swab, impregnated drug Garazon ® . The tampon must be maintained wet, soaking his medication every four hours. Every 24 hours, the tampon should be changed. In chronic diseases of the eyes and ears of the termination of treatment Garazon ® should be done gradually by reducing the frequency of application.
after use possible short-term appearance of a burning sensation, itching or dryness of the skin at the application site.
Adverse events associated with the action of corticosteroids in the eye include increased intraocular pressure, glaucoma, optic nerve damage, decreased visual acuity and visual field loss, the development of the back subcapsular cataract, delayed wound healing, the penetration of air bubbles after cataract surgery, the development of secondary infections of the eye (eg, Herpes Zoster), acute anterior uveitis, perforation of the cornea and sclera, mydriasis, disturbance of accommodation and ptosis.
When you use antibiotics for the treatment of the eye may develop allergic reactions. It reported transient eye irritation in connection with the use of gentamicin sulfate.
Overdose symptoms . With prolonged use of high doses of corticosteroids – the suppression of the hypothalamic-pituitary-adrenal system, hypercortisolism, aminoglycosides – ototoxic effects. Treatment .Gradual removal of the drug, if necessary – symptomatic therapy, including correction fluid and electrolyte imbalance.
Interaction with other drugs
of any drug interaction GARAZON ® with other drugs have been reported.
Garazon ® is intended for topical use. The drug should not be administered as an injection subkonyunktivalno or directly into the anterior chamber of the eye.
The absence of rapid clinical effect when used Garazon drug ® may be cause for further investigation in order to clarify the diagnosis.
When you save the signs of the disease, or in the event of a relapse, despite all the course of treatment drug, it is desirable to conduct bacteriological examination of smears from the conjunctiva to determine the sensitivity of the pathogen to antibiotics.
in appointing the drug Garazon ® for 10 days term and more necessary to measure intraocular pressure. It is recommended to conduct research and the tonometry eye with a slit lamp. Patients who have a family history which has ill open angle glaucoma, high myopia or diabetes are risk group increased intraocular pressure due to topical treatment of corticosteroids.
It is known that in diseases that cause thinning of the cornea or sclera, topical application of corticosteroids may cause perforation eyeball. In this regard, it is not recommended to start with the application of a combination of “antibiotic-inflammatory agent” treating corneal ulcers bacterial etiology which may be caused by Pseudomonas aeruginosa. It is advisable to use only antibacterial agent only at the beginning. If there is a response to antibiotic therapy, it may be recommended to attach to the treatment of anti-inflammatory agent to minimize the fibrotic reaction and prevent the formation of corneal scar.
In acute purulent processes in the eye GCS can mask existing infection or potentiate it.
In the treatment of infections caused by herpes simplex virus , corticosteroids should be used with extreme caution.
in the case of topical administration of an antibiotic of the aminoglycoside should bear in mind the possibility of ototoxicity.
animal studies have shown that gentamicin when applied topically in the external auditory canal can be absorbed into the blood, because after destination in this way, he was determined serum and urine.Long term use of topical corticosteroids, or antibiotics may lead to increased growth insensitive microorganisms, including fungi. Between various aminoglycosides and SSC were noted cross-allergic reaction.
In order to avoid contamination and cross-infection, one should not use a vial preparation for simultaneous treatment of eye and ear infections. In the case of an open end touching the dropper bottle to any surface contamination of the solution may occur. Using a dropper bottle, more than one person may spread infection.
With long-term treatment of drug recommended its abolition gradually. Paediatric use . The safety and efficacy of the drug Garazon ® in children under the age of 8 years has not been established.
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