nandrolone phenylpropionate profile
Each tablet contains: Active ingredient: 20 mg nandrolone phenylpropionate profile. Excipients: Core – lactose, corn starch, colloidal silicon dioxide, magnesium stearate Shell – hypromellose, hydroxypropyl cellulose, propylene glycol 6000, iron oxide red, yellow iron oxide, talc, titanium dioxide.
Light-beige, biconvex, round tablet with a white core coated.
Pharmacotherapeutic group : anti-ulcer agent – H 2 histamine receptor blocker.
Pharmacological properties Pharmacodynamics . Blocker H 2 III generation histamine receptors. Suppress basal and stimulated by histamine, gastrin and acetylcholine production of hydrochloric acid. Reduces the activity of pepsin. Increases gastric mucosal defenses and promotes healing associated with exposure to hydrochloric acid it damages (including cessation of gastrointestinal bleeding and scarring of stress ulcers) by increasing the formation of gastric mucus, its content of glycoproteins, stimulating the secretion of bicarbonate gastric mucosa, endogenous synthesis of prostaglandins in it and recovery rate. It did not significantly alter the concentration of gastrin in plasma. Weakly inhibit cytochrome oxidase P450 system in the liver. After ingestion action begins 1 hour reaches the maximum within 3 hours. The duration of action of the drug in single intake dose-dependent and ranges from 12 to 24 hours. Pharmacokinetics . After oral administration, rapidly absorbed from the gastrointestinal tract. After oral administration the maximum plasma concentration is reached within 1-3.5 hours.Bioavailability – 40-45%, increased when taken with food, and is reduced by intake of antacids. Relationship to plasma proteins – 15-20%. nandrolone phenylpropionate profile 30-35% metabolized in the liver (to form S-oxide). Elimination mainly takes place through the kidneys: 27-40% of the drug is excreted in the urine in unchanged form. The half – 2.5-4 hours, in patients with a creatinine clearance less than 30 mL / min is increased to 10-12 hours. In patients with severe renal impairment (creatinine clearance less than 10 mL / min), it increases to 20 hours. It penetrates through the placental barrier and is excreted in breast milk.
Indications for use .
Peptic ulcer disease 12 duodenal ulcer and stomach in the acute phase, prevention of relapses.
Treatment and prevention of symptomatic gastric ulcers and 12 duodenal ulcer (associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), stress, postoperative ulcers).
Functional dyspepsia associated with increased secretion of the stomach.
Prevention of relapse of bleeding from the upper gastrointestinal tract.
Prevention of aspiration of gastric juice during general anesthesia (Mendelson’s syndrome).
Pregnancy, lactation, hepatic failure, infancy, hypersensitivity to the drug.
Be wary – cirrhosis with portosystemic encephalopathy in history, liver dysfunction, kidney failure.
Dosing and Administration
Inside. In gastric ulcer and 12 duodenal ulcer in the acute phase, symptomatic ulcers, erosive gastroduodenitis usually administered 20 mg 2 times a day or 40 mg 1 time a day at night. The daily dose can be increased to 80-160 mg if necessary. The course of treatment – 4-8 weeks. When dyspepsia associated with increased secretion of the stomach, administered 20 mg 1-2 times a day.
In order to prevent a recurrence of peptic ulcer appoint 20 mg 1 time a day at bedtime.
When reflux esophagitis – 20-40 mg 2 times daily for 6-12 weeks.
When Zollinger-Ellison syndrome, the dose and duration of treatment is determined individually. The initial dose is typically 20 mg every 6 hours and can be increased to 160 mg every 6 hours.
To prevent aspiration of gastric juice under general anesthesia with 40 mg administered in the evening / or the morning of surgery. Tablets should be swallowed without chewing, drinking plenty of water.
In renal failure, if creatinine clearance less than 30 ml / min or creatinine in the blood serum of more than 3 mg / 100 ml, the daily dose should be reduced to 20 mg.
Side effect . From the digestive system: dry mouth, nausea, vomiting, abdominal pain, loss of appetite, increased activity of “liver” transaminases, hepatitis, acute pancreatitis. From the nervous system:headache, dizziness, hallucinations, confusion. With cardio-vascular system: decrease in blood pressure, atrio-ventricular block, bradycardia. Allergic reactions: dry skin, urticaria, pruritus, rash, bronchospasm, angioedema, anaphylactic shock. From the side of hematopoiesis: rarely leukopenia, thrombocytopenia, in rare cases – agranulocytosis, pancytopenia, hypoplasia, aplasia of the bone marrow.reproductive system: chronic administration of high doses – giperlaktinemiya, gynecomastia, aminoreya, decreased libido, impotence. From the senses: paresis of accommodation, blurred vision, ringing in the ears . Other: rarely – fever, arthralgia, myalgia.
Symptoms: vomiting, motor excitation, tremors, decreased blood pressure, tachycardia, collapse.
Interaction with other medicinal products .
As a result of increasing the pH of the stomach contents, while the reception can decrease the absorption of ketoconazole and itraconazole.
In an application with antacids, sucralfate occurs absorption intensity decrease nandrolone phenylpropionate profile, so the interval between administration of these medications must be at least 1-2 hours.
Increased absorption of amoxicillin and clavulanic acid.
Drugs that suppress the bone marrow, increasing the risk of developing neutropenia.
Before treatment is necessary to exclude the possibility of malignant diseases of the esophagus, stomach or duodenum. nandrolone phenylpropionate profile, like all the H 2 histamine blockers, undesirable sharply cancel ( “ricochet” syndrome). With prolonged treatment in immunocompromised patients under stress, possible bacterial lesions of the stomach and then spread the infection. Blockers H 2 gistaminoretseptorov may counteract the effects of pentagastrin and histamine on acid-forming function of the stomach, so in the preceding test, use H blockers within 24 hours 2 -gistaminoretseptorov not recommended. Blockers H 2 -gistaminoretseptorov can inhibit the skin reaction to histamine, thus leading to false-negative results (prior to diagnostic skin tests for the detection of allergic skin reactions immediate type blockers H 2 -gistaminoretseptorov recommended stop). During treatment should avoid eating foods, drinks and other drugs that can cause irritation of the gastric mucosa.
Effects on ability to drive and use other machinery .
The treatment should be careful when driving and other activities that require high concentration and speed of psychomotor reactions.
10 tablets in a blister of PVC film laminated with aluminum foil. By 1 or 3 blisters with instruction on use is placed in a cardboard box. steroids meningitis pharma grade testosterone steroids 4 sale bodybuilding coupon code 10 percent novorapid insulin flexible dieting bodybuilding